Dr. Anshuman Sewda

Dr. Anshuman Sewda

Assistant Professor

Dr. Anshuman Sewda is a genetic epidemiologist with more than 10 years of academic and research experience in the United States. He obtained his MPH (Epidemiology) and PhD (Epidemiology) degrees from the University of Texas (UTHealth) School of Public Health, Houston, TX, USA, and received Rufus K. Guthrie Scholarship and President James T. & Nancy B. Willerson Scholarship. He gave an invited talk on his doctoral dissertation at the National Institutes of Health (11th Structural Birth Defects Meeting, NIH/NICHD, Bethesda, MD, USA). Dr. Sewda has been inducted into the prestigious Delta Omega Honorary Society in Public Health (Alpha Iota Chapter; founded in 1924). While in Houston, Dr. Sewda worked at several prestigious institutions, such as the M.D. Anderson Cancer Center (frequently ranked #1 cancer hospital in the US), Human Genetics Center (UTHealth), and McGovern Medical School (UTHealth). Later, he completed a 3-year postdoctoral fellowship in New York City in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, where he worked on two of the world’s largest genomics research cohorts: 1) Craniosynostosis Network Consortium in collaboration with several US-based and international institutions, including University of Oxford (UK), University of Heidelberg (Germany), University of Bordeaux (France), and Hospital Sant Joan De Déu (Spain); and 2) Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) genetics project in collaboration with University of Washington and other US-based institutions. His work from these projects has been presented at the NIH. Dr. Sewda identified novel coding genetic variants associated with nonsyndromic craniosynostosis, and his first-author paper was featured on the cover of the Pediatric Research (Nature) journal. He has published articles in reputed international journals, such as European Journal of Human Genetics (Nature), Pediatric Research (Nature), Circulation: Cardiovascular Genetics (Circulation: Genomic and Precision Medicine), Journal of Cardiovascular Magnetic Resonance (BMC, part of Springer Nature), PLOS One, and Birth Defects Research. He serves as a reviewer for several reputed international journals, such as Birth Defects Research, Molecular Genetics and Genomic Medicine, Paediatric and Perinatal Epidemiology, Journal of Pediatric Neurology, and Cardiology in the Young (Cambridge).

  • Genetic and environmental risk factors of congenital disorders (birth defects)
  • Maternal genetic and non-genetic risk factors of birth defects
  • Genome-wide association studies (GWAS) and post-GWAS approaches
  • Family-based genetic studies
  • Cardiovascular diseases
  • Chronic diseases
Past Projects
  • Center for AIDS Research Network of Integrated Clinical Systems (CNICS) Consortium (USA), Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA (2017–2019)
  • Craniosynostosis Network Consortium, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA (2016–2019)
  • Pediatric Cardiac Genomics Consortium (PCGC), Human Genetics Center, University of Texas Health Science Center (UTHealth), Houston, TX, USA (2012–2019)
  • National Birth Defects Prevention Study (NBDPS), Human Genetics Center, University of Texas Health Science Center (UTHealth), Houston, TX, USA (2012–2016)
  • Spina Bifida Research Resource (SBRR), Human Genetics Center, University of Texas Health Science Center (UTHealth), Houston, TX, USA (2012–2013)
  • Atherosclerosis Risk in Communities (ARIC) Study, Human Genetics Center, University of Texas Health Science Center (UTHealth), Houston, TX, USA (2009–2012)
Selected Publications
  • Sewda A, Agopian AJ, Goldmuntz E, Hakonarson H, Morrow BE, Musfee F, Taylor D, Mitchell LE, Pediatric Cardiac Genomics Consortium (2020). Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects. PLOS ONE, 15(6):e0234357. DOI: https://doi.org/10.1371/journal.pone.0234357
  • Hoang TT, Manso PH, Edman S, Mercer-Rosa L, Mitchell LE, Sewda A, Swartz MD, Fogel MA, Agopian AJ, Goldmuntz E (2019). Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients. Journal of Cardiovascular Magnetic Resonance, 2019;21(1):51. DOI: https://doi.org/10.1186/s12968-019-0555-2
  • Sewda A, Agopian AJ, Goldmuntz E, Hakonarson H, Morrow B, Taylor D, Mitchell LE, on behalf of Pediatric Cardiac Genomics Consortium (2019). Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects. PLOS ONE. 14(7):e0219926. DOI: https://doi.org/10.1371/journal.pone.0219926
  • Sewda A, White SR, Erazo M, Hao K, García-Fructuoso G, Fernández-Rodriguez I, Heuzé Y, Richtsmeier JT, Romitti P, Reva B, Jabs EW, Peter I (2019). Nonsyndromic craniosynostosis: novel coding variants. Pediatric Research, 85(4):463-468. DOI: https://doi.org/1038/s41390-019-0274-2
  • Sewda A, White SR, Erazo M, Hao K, García-Fructuoso G, Fernández-Rodriguez I, Heuzé Y, Richtsmeier JT, Romitti P, Reva B, Jabs EW, Peter I (2019). Nonsyndromic craniosynostosis: novel coding variants. Pediatric Research 85(4) issue: Cover Image: https://www.nature.com/pr/volumes/85/issues/4
  • Granot-Hershkovitz E, Karasik D, Friedlander Y, Rodriguez-Murillo L, Dorajoo R, Liu J, Sewda A, Peter I, Carmi S, Hochner H (2018). A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure. European Journal of Human Genetics, 26(12), 1848-1858. DOI: https://doi.org/1038/s41431-018-0230-3
  • Agopian AJ, Goldmuntz E, Hakonarson H, Sewda A, Taylor D, Mitchell LE, on behalf of Pediatric Cardiac Genomics Consortium (2017). Genome-wide association studies and meta-analyses for congenital heart defects. Circulation: Cardiovascular Genetics, 10, e001449. DOI: https://doi.org/1161/CIRCGENETICS.116.001449
  • Agopian AJ, Mitchell LE, Glessner J, Bhalla AD, Sewda A, Hakonarson H, Goldmuntz E (2014). Genome-wide association study of maternal and inherited loci for conotruncal heart defects. PLOS ONE, 9, e96057. DOI: https://doi.org/1371/journal.pone.0096057
  • Agopian AJ, Bhalla AD, Boerwinkle E, Finnell RH, Grove ML, Hixson JE, Shimmin LC, Sewda A, Stuart C, Zhong Y, Zhu H, Mitchell LE (2013). Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida. Birth Defects Research. Part A: Clinical and Molecular Teratology, 97, 597-601. DOI: https://doi.org/10.1002/bdra.23163

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